Quinolines and derivatives
Medchemexpress LLC IL-31 protein, mouse (HEK293, His) | >85.0% | 100 UG
Recombinant mouse interleukin-31 (IL-31) expressed in HEK293 cells and supplied as a 0.22 μm filtered PBS solution. The protein carries a C-terminal His tag, is >85% pure by reducing SDS-PAGE, and shows functional activity in receptor binding ELISA (ED50 = 2.916 μg/mL). It is intended for in vitro signaling, receptor binding, and assay development.
Medchemexpress LLC 7-bromoquinoline-4-carboxylic acid | 31009-04-8 | MFCD11108751 | 96.1% | 252.06 | C10H6BrNO2 | 1 G
7-Bromoquinoline-4-carboxylic acid is a brominated quinoline carboxylic acid used as an intermediate in organic synthesis and medicinal chemistry research. It is supplied as a gray to brown solid (C10H6BrNO2; MW 252.06; CAS 31009-04-8) with typical HPLC purity of 96.12%. Storage recommendations: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
- Used as an intermediate for organic synthesis
- Suitable for medicinal chemistry research applications
- Supplied as a stable solid with defined storage conditions
- Provided with HPLC purity data for quality assessment
- Batch certificate of analysis available for traceability
Medchemexpress LLC Fatostatin (125B11) | 125256-00-0 | 98.2% | C18H18N2S | 200 MG
Fatostatin (125B11) is a specific inhibitor of SREBP activation that impairs the activation of SREBP-1 and SREBP-2. It binds to SCAP (SREBP cleavage-activating protein) and inhibits the ER-Golgi translocation of SREBPs. Fatostatin decreases the transcription of lipogenic genes in cells. It also possesses antitumor properties and lowers hyperglycemia in ob/ob mice.
- Specific inhibitor of SREBP activation.
- Impairs activation of SREBP-1 and SREBP-2.
- Binds to SCAP and inhibits ER-Golgi translocation of SREBPs.
- Decreases transcription of lipogenic genes in cells.
- Possesses antitumor properties.
- Lowers hyperglycemia in ob/ob mice.
- Inhibits androgen-independent prostate cancer cell proliferation.
- Inhibits insulin-induced adipogenesis of 3T3-L1 cells.
- Reduced adiposity and ameliorated fatty liver in ob/ob mice.
Medchemexpress LLC Mal-amido-PEG12-acid | 2378428-27-2 | C34H60N2O17 | 50 MG
Mal-amido-PEG12-acid is a PEG-based PROTAC linker suitable for synthesizing PROTACs. It functions by connecting two distinct ligands, one targeting an E3 ubiquitin ligase and the other for the specific target protein, allowing for the selective degradation of target proteins through the intracellular ubiquitin-proteasome system.
- Can be used in the synthesis of PROTACs.
- Exploits the intracellular ubiquitin-proteasome system.
- Selectively degrades target proteins.
Medchemexpress LLC Azide-PEG-amine | 95.0% | 100 MG
Azide-PEG-amine (MW 5000) is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This molecule functions as a versatile click chemistry reagent, enabling crucial reactions in chemical biology and drug discovery.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne groups
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups
Medchemexpress LLC MPEG-amine (MW 20000) | 80506-64-5 | 98.0% | (C2H4O)nC3H9NO | 100 MG
m-PEG-NH2 (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- Peg-based PROTAC linker
- Used in the synthesis of PROTACs
- Purity: 98.0%
Medchemexpress LLC PI3K-IN-31 | 1359956-12-9 | 99.3% | C19H23F2N7O3 | 100 MG
PI3K-IN-31 (Compound 6b) is a potent PI3K inhibitor that has demonstrated anticancer effects. It selectively inhibits PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ with varying IC50 values.
- Potent PI3K inhibitor
- Exhibits anticancer effects
- Selectively inhibits PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ
Medchemexpress LLC ACT-1004-1239 | 2178049-58-4 | 98.8% | C27H28F2N6O3 | 50 MG
ACT-1004-1239 is a potent, selective, and orally active CXCR7 antagonist with an IC50 value of 3.2 nM. It promotes oligodendrocyte precursor cell (OPC) differentiation by increasing CXCL12 levels. In animal models, it has been shown to reduce disease severity in myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) and increase myelination in Cuprizone-induced demyelination models. This product is for research use only.
- Potent, selective, and orally active CXCR7 antagonist
- IC50 value of 3.2 nM
- Promotes oligodendrocyte precursor cell (OPC) differentiation
- Increases CXCL12 levels
- Reduces disease severity in MOG-induced experimental autoimmune encephalomyelitis (EAE) in animal models
- Increases myelination in Cuprizone-induced demyelination models
- For research use only
Medchemexpress LLC ACT-1004-1239 | 2178049-58-4 | 98.8% | C27H28F2N6O3 | 1 MG
ACT-1004-1239 is a potent, selective, orally active CXCR7 antagonist with an IC50 value of 3.2 nM. It is intended for research use only.
- Inhibits human, dog, rat, mouse, guinea pig, macaque CXCR7 with IC50s of 3.2, 2.3, 3.1, 2.3, 0.6, 1.5 nM respectively.
- Promotes oligodendrocyte precursor cell (OPC) differentiation by increasing CXCL12 levels.
- Increases plasma CXCL12 concentration in naive male DBA/1 mice.
- Reduces disease severity in MOG-induced experimental autoimmune encephalomyelitis (EAE) model.
- Increases myelination in the Cuprizone-induced demyelination model mice.
Medchemexpress LLC Aripiprazole | 129722-12-9 | 99.95% | 200 MG
Aripiprazole is an atypical antipsychotic that acts as a potent and high-affinity dopamine D2 receptor partial agonist. It also functions as an inverse agonist at 5-HT2B and 5-HT2A receptors and exhibits partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. This compound is suitable for research into conditions such as schizophrenia and COVID19.
- Atypical antipsychotic
- Potent and high-affinity dopamine D2 receptor partial agonist
- Acts as an inverse agonist at 5-HT2B and 5-HT2A receptors
- Exhibits partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors
- Can be used for the research of schizophrenia and COVID19
Medchemexpress LLC Kaempferol | 520-18-3 | MFCD00004543 | 99.9% | C15H10O6 | 200 MG
Kaempferol is a naturally occurring flavonoid found in various edible plants. This compound functions as an estrogen receptor alpha inhibitor in breast cancer cells and promotes apoptosis in glioblastoma and lung cancer cells through MEK-MAPK activation. It is recognized as a human endogenous metabolite.
- Inhibits estrogen receptor alpha expression in breast cancer cells.
- Induces apoptosis in glioblastoma and lung cancer cells.
- Demonstrates anti-inflammatory activity.
- Exhibits antioxidant activity in human HepG2 cells.
- Shows antiproliferative activity against certain human cancer cell lines.
- Displays antiallergic activity.
- Demonstrates antiviral activity against influenza A virus.
- Inhibits melanogenesis.
- Inhibits procoagulant activity.
- Induces osteoclast apoptosis.
- Exhibits antiaggregatory activity in human platelets.
Medchemexpress LLC Amine-PEG-amine (MW 5000) | 95.0% | 100 MG
Amine-PEG-amine (MW 5000) is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are compounds consisting of two distinct ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets a protein of interest. This mechanism exploits the intracellular ubiquitin-proteasome system to achieve selective degradation of target proteins. The product is intended for research use only.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system to achieve selective degradation of target proteins
- Intended for research use only
- Solid appearance
- White to off-white color
- Molecular weight of 5000 (average)
- 95.0% purity
Medchemexpress LLC Z-LYS-SBZL monohydrochloride | 69861-89-8 | 99.7% | C21H27ClN2O3S | 25 MG
Z-LYS-SBZL monohydrochloride (α-N-Carbobenzoxy-L-lysine thiobenzyl ester monohydrochloride) is a lysine derivative primarily intended for research use. Amino acids and their derivatives, like this product, are recognized as beneficial ergogenic dietary substances. It is designed to support various biological activities related to physical and mental performance.
- Influences anabolic hormone secretion
- Supplies fuel during exercise
- Enhances mental performance during stress-related tasks
- Prevents exercise-induced muscle damage
- For research use only
Medchemexpress LLC Azido-PEG10-amine | 912849-73-1 | MFCD03453246 | ≥97.0% | C22H46N4O10 | 5 G
Azido-PEG10-amine is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group that allows it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions. PROTACs themselves are designed to exploit the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- Functions as a click chemistry reagent
- Contains an azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
- Engages in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Utilized in the synthesis of PROTACs